PDBe 4w9x

X-ray diffraction
2.14Å resolution

Crystal Structure of BMP-2-inducible kinase in complex with baricitinib

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BMP-2-inducible protein kinase Chain: A
Molecule details ›
Chain: A
Length: 310 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NSY1 (Residues: 38-345; Coverage: 27%)
Gene names: BIKE, BMP2K, HRIHFB2017
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: I222
Unit cell:
a: 42.31Å b: 111.41Å c: 163.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.229
Expression system: Escherichia coli BL21(DE3)