PDBe 4w7p

X-ray diffraction
2.8Å resolution

Crystal Structure of ROCK 1 bound to YB-15-QD37


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Rho-associated protein kinase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 411 amino acids
Theoretical weight: 47.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q13464 (Residues: 2-410; Coverage: 30%)
Gene name: ROCK1
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 61.545Å b: 179.659Å c: 89.269Å
α: 90° β: 104.59° γ: 90°
R R work R free
0.208 0.206 0.246
Expression system: Spodoptera frugiperda