PDBe 4v01

X-ray diffraction
2.33Å resolution

FGFR1 in complex with ponatinib (co-crystallisation).

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 35.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: D3DSX2 (Residues: 22-329; Coverage: 80%)
Gene names: FGFR1, hCG_23105
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: C2
Unit cell:
a: 207.255Å b: 58.09Å c: 65.231Å
α: 90° β: 107.38° γ: 90°
R-values:
R R work R free
0.191 0.189 0.238
Expression system: Escherichia coli