PDBe 4uyz

X-ray diffraction
2.8Å resolution

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM II - 2.8A

Released:

Function and Biology Details

Reaction catalysed:
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H(2)O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate
Biochemical function:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Palmitoleoyl-protein carboxylesterase NOTUM Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 471 amino acids
Theoretical weight: 53.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P988 (Residues: 38-496; Coverage: 96%)
Gene names: NOTUM, OK/SW-CL.30
Sequence domains: Pectinacetylesterase
POLY ALA Chain: E
Molecule details ›
Chain: E
Length: 10 amino acids
Theoretical weight: 729 Da
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 60.829Å b: 193.88Å c: 75.717Å
α: 90° β: 91.88° γ: 90°
R-values:
R R work R free
0.249 0.248 0.293
Expression system: Homo sapiens