PDBe 4uip

X-ray diffraction
2.95Å resolution

The complex structure of extracellular domain of EGFR with Repebody (rAC1).

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 618 amino acids
Theoretical weight: 68.59 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 26-637; Coverage: 52%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Internalin B; Variable lymphocyte receptor B Chain: B
Molecule details ›
Chain: B
Length: 251 amino acids
Theoretical weight: 28.3 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q4G1L3 (Residues: 55-59, 73-75, 78-101, 107-232; Coverage: 56%)
  • Canonical: E0ACT6 (Residues: 33-98, 104-114, 118-119, 142-146; Coverage: 50%)
  • nullnull
Gene names: VLRB, inlB
Sequence domains: Leucine rich repeat

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-1A
Unit cell:
a: 66.79Å b: 88.34Å c: 189.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.237 0.297
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli