PDBe 4ui1

X-ray diffraction
2.35Å resolution

Crystal structure of the human RGMC-BMP2 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bone morphogenetic protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 114 amino acids
Theoretical weight: 12.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12643 (Residues: 283-396; Coverage: 31%)
Gene names: BMP2, BMP2A
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Hemojuvelin Chains: C, D
Molecule details ›
Chains: C, D
Length: 122 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6ZVN8 (Residues: 35-145; Coverage: 28%)
Gene names: HFE2, HJV, RGMC

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 69.04Å b: 76.29Å c: 81.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.238
Expression systems:
  • Escherichia coli BL21(DE3)
  • Homo sapiens