PDBe 4uae

X-ray diffraction
2.7Å resolution

Importin alpha 3 delta IBB in complex with Influenza PB2 Nuclear Localization Domain


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-3 Chain: A
Molecule details ›
Chain: A
Length: 421 amino acids
Theoretical weight: 46.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O00629 (Residues: 68-487; Coverage: 81%)
Gene names: KPNA4, QIP1
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Polymerase basic protein 2 Chain: F
Molecule details ›
Chain: F
Length: 87 amino acids
Theoretical weight: 9.34 KDa
Source organism: Influenza A virus (A/Victoria/3/1975(H3N2))
Expression system: Escherichia coli
  • Canonical: P31345 (Residues: 678-759; Coverage: 11%)
Gene name: PB2
Structure domains: Defensin A-like

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P41
Unit cell:
a: 135.682Å b: 135.682Å c: 47.309Å
α: 90° β: 90° γ: 90°
R R work R free
0.188 0.185 0.239
Expression system: Escherichia coli