PDBe 4uad

X-ray diffraction
2.42Å resolution

Importin alpha 7 delta IBB in complex with Influenza PB2 Nuclear Localization Domain


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-7 Chain: A
Molecule details ›
Chain: A
Length: 479 amino acids
Theoretical weight: 52.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O60684 (Residues: 59-536; Coverage: 89%)
Gene names: IPOA7, KPNA6
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Polymerase basic protein 2 Chain: E
Molecule details ›
Chain: E
Length: 77 amino acids
Theoretical weight: 8.38 KDa
Source organism: Influenza A virus (A/Victoria/3/1975(H3N2))
Expression system: Escherichia coli
  • Canonical: P31345 (Residues: 683-759; Coverage: 10%)
Gene name: PB2
Structure domains: Defensin A-like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: C2
Unit cell:
a: 242.315Å b: 38.836Å c: 67.898Å
α: 90° β: 98.03° γ: 90°
R R work R free
0.193 0.189 0.231
Expression system: Escherichia coli