PDBe 4u2x

X-ray diffraction
3.15Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Membrane-associated protein VP24 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 216 amino acids
Theoretical weight: 24.42 KDa
Source organism: Ebola virus - Mayinga, Zaire, 1976
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q05322 (Residues: 16-231; Coverage: 86%)
Gene name: VP24
Importin subunit alpha-6 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 175 amino acids
Theoretical weight: 19.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15131 (Residues: 329-503; Coverage: 33%)
Gene name: KPNA5
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 103.925Å b: 103.925Å c: 333.63Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.215 0.249
Expression system: Escherichia coli BL21(DE3)