PDBe 4u1r

X-ray diffraction
2.8Å resolution

ATP-bound structure of human platelet phosphofructokinase in an R-state, crystal form II


Function and Biology Details

Reaction catalysed:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
ATP-dependent 6-phosphofructokinase, platelet type Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 743 amino acids
Theoretical weight: 81.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q01813 (Residues: 26-762; Coverage: 94%)
Gene names: PFKF, PFKP
Sequence domains: Phosphofructokinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P3221
Unit cell:
a: 132.896Å b: 132.896Å c: 399.105Å
α: 90° β: 90° γ: 120°
R R work R free
0.164 0.162 0.198
Expression system: Escherichia coli BL21(DE3)