PDBe 4u18

X-ray diffraction
2.64Å resolution

Crystal structure of human peroxisomal delta3,delta2, enoyl-CoA isomerase (ISO-ECI2)

Released:

Function and Biology Details

Reaction catalysed:
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enoyl-CoA delta isomerase 2, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 276 amino acids
Theoretical weight: 30.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75521 (Residues: 138-390; Coverage: 64%)
Gene names: DRS1, ECI2, HCA88, PECI
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 76.428Å b: 91.915Å c: 130.368Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.194 0.262
Expression system: Escherichia coli