PDBe 4u17

X-ray diffraction
1.99Å resolution

Swapped dimer of the human Fyn-SH2 domain

Released:
Source organism: Homo sapiens
Entry authors: Garcia-Pino A, Huculeci R, Lenaerts T, van Nuland NAJ

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 105 amino acids
Theoretical weight: 12.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 148-248; Coverage: 19%)
Gene name: FYN
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 88.965Å b: 57.873Å c: 101.188Å
α: 90° β: 90.6° γ: 90°
R-values:
R R work R free
0.209 0.207 0.255
Expression system: Escherichia coli BL21(DE3)