› 4u17

X-ray diffraction
1.99Å resolution

Swapped dimer of the human Fyn-SH2 domain

Released:
DOI: 10.2210/pdb4u17/pdb
PDB entry 4u17 coloured by chain, front view.
PDB entry 4u17 coloured by chain, side view.
PDB entry 4u17 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Garcia-Pino A, Huculeci R, Lenaerts T, van Nuland NAJ

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138972 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 105 amino acids
Theoretical weight: 12.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 148-248; Coverage: 19%)
Gene name: FYN
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

2 bound ligands:
Ligand PO4 7 x PO4
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 88.965Å b: 57.873Å c: 101.188Å
α: 90° β: 90.6° γ: 90°
R-values:
R R work R free
0.209 0.207 0.255
Expression system: Escherichia coli BL21(DE3)

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