PDBe 4tye

X-ray diffraction
2.8Å resolution

Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P22455 (Residues: 447-753; Coverage: 39%)
Gene names: FGFR4, JTK2, TKF
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43212
Unit cell:
a: 61.948Å b: 61.948Å c: 184.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.223 0.278
Expression system: Spodoptera frugiperda