PDBe 4twp

X-ray diffraction
2.4Å resolution

The crystal structure of human abl1 T315I gatekeeper mutant kinase domain in complex with axitinib

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 31.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00519 (Residues: 233-503; Coverage: 24%)
Gene names: ABL, ABL1, JTK7
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Unit cell:
a: 56.818Å b: 113.801Å c: 131.164Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.212 0.241
Expression system: Spodoptera frugiperda