PDBe 4tqe

X-ray diffraction
1.6Å resolution

Structure of tau peptide in complex with Tau5 antibody Fab fragment

Released:
Source organisms:
Entry authors: Cehlar O, Skrabana R, Novak M

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
If kappa light chain Chain: L
Molecule details ›
Chain: L
Length: 218 amino acids
Theoretical weight: 24.1 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: A2NHM3 (Residues: 1-218; Coverage: 100%)
Gene names: Igk-C, Igkc
Sequence domains:
Structure domains: Immunoglobulins
Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.9 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Microtubule-associated protein tau Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 532-547; Coverage: 2%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: C2
Unit cell:
a: 124.865Å b: 59.732Å c: 71.041Å
α: 90° β: 112.76° γ: 90°
R-values:
R R work R free
0.154 0.151 0.197
Expression system: Not provided