PDBe 4tlu

X-ray diffraction
1.75Å resolution

Crystal Structure of Human Transthyretin Ala108Trp Mutant

Released:
Source organism: Homo sapiens
Entry authors: Saelices L, Cascio D, Sawaya M, Eisenberg DS

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 29-147; Coverage: 94%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 42.7Å b: 85.57Å c: 63.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.213
Expression system: Escherichia coli BL21(DE3)