PDBe 4tls

X-ray diffraction
1.35Å resolution

Crystal Structure of Human Transthyretin Glu92Pro Mutant

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 13.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 29-147; Coverage: 94%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 42.38Å b: 86.08Å c: 64.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.192
Expression system: Escherichia coli BL21(DE3)