PDBe 4rrv

X-ray diffraction
1.41Å resolution

Crystal structure of PDK1 in complex with ATP and PIFtide

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase N2 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16513 (Residues: 969-983; Coverage: 2%)
Gene names: PKN2, PRK2, PRKCL2
3-phosphoinositide-dependent protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 35.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15530 (Residues: 50-359; Coverage: 56%)
Gene names: PDK1, PDPK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2
Unit cell:
a: 148.973Å b: 44.536Å c: 47.799Å
α: 90° β: 101.4° γ: 90°
R-values:
R R work R free
0.135 0.134 0.163
Expression systems:
  • Not provided
  • Spodoptera frugiperda