PDBe 4rmi

X-ray diffraction
1.45Å resolution

Human Sirt2 in complex with SirReal1 and Ac-Lys-OTC peptide


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD-dependent protein deacetylase sirtuin-2 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8IXJ6 (Residues: 56-356; Coverage: 77%)
Gene names: SIR2L, SIR2L2, SIRT2
Sequence domains: Sir2 family
Structure domains:
Ac-Lys-OTC peptide Chain: B
Molecule details ›
Chain: B
Length: 3 amino acids
Theoretical weight: 475 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 36.212Å b: 73.745Å c: 55.858Å
α: 90° β: 94.71° γ: 90°
R R work R free
0.261 0.26 0.282
Expression systems:
  • Escherichia coli
  • Not provided