PDBe 4rmh

X-ray diffraction
1.42Å resolution

Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD-dependent protein deacetylase sirtuin-2 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8IXJ6 (Residues: 56-356; Coverage: 77%)
Gene names: SIR2L, SIR2L2, SIRT2
Sequence domains: Sir2 family
Structure domains:
Ac-Lys-H3 peptide Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 729 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 35.994Å b: 73.302Å c: 55.291Å
α: 90° β: 95.23° γ: 90°
R R work R free
0.181 0.181 0.188
Expression systems:
  • Escherichia coli
  • Not provided