PDBe 4rdd

X-ray diffraction
1.6Å resolution

Co-crystal structure of SHP2 in complex with a Cefsulodin derivative


Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein phosphatase non-receptor type 11 Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 32.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q06124 (Residues: 262-532; Coverage: 45%)
  • Best match: Q06124-3 (Residues: 262-459)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 39.638Å b: 75.274Å c: 48.046Å
α: 90° β: 99.11° γ: 90°
R R work R free
0.176 0.175 0.201
Expression system: Escherichia coli BL21(DE3)