PDBe 4r8m

X-ray diffraction
2.1Å resolution

Human SIRT2 crystal structure in complex with BHJH-TM1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD-dependent protein deacetylase sirtuin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 319 amino acids
Theoretical weight: 36.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IXJ6 (Residues: 38-356; Coverage: 82%)
Gene names: SIR2L, SIR2L2, SIRT2
Sequence domains: Sir2 family
Structure domains:
BHJH-TM1 peptide Chains: C, D
Molecule details ›
Chains: C, D
Length: 5 amino acids
Theoretical weight: 532 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 36.936Å b: 116.799Å c: 70.905Å
α: 90° β: 91.77° γ: 90°
R-values:
R R work R free
0.224 0.221 0.273
Expression systems:
  • Escherichia coli
  • Not provided