PDBe 4r7p

X-ray diffraction
3.35Å resolution

Human UDP-glucose pyrophosphorylase isoform 1 in complex with UDP-glucose

Released:

Function and Biology Details

Reaction catalysed:
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UTP--glucose-1-phosphate uridylyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 526 amino acids
Theoretical weight: 58.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16851 (Residues: 2-508; Coverage: 100%)
  • Best match: Q16851-2 (Residues: 1-497)
Gene names: UGP1, UGP2
Sequence domains: UTP--glucose-1-phosphate uridylyltransferase
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P3121
Unit cell:
a: 138.97Å b: 138.97Å c: 311.62Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.199 0.247
Expression system: Escherichia coli