PDBe 4qjr

X-ray diffraction
2.4Å resolution

Crystal structure of human nuclear receptor sf-1 (nr5a1) bound to its hormone pip3 at 2.4 a resolution

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Steroidogenic factor 1 Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 27.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13285 (Residues: 218-461; Coverage: 53%)
Gene names: AD4BP, FTZF1, NR5A1, SF1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UBK2 (Residues: 139-152; Coverage: 2%)
Gene names: LEM6, PGC1, PGC1A, PPARGC1, PPARGC1A

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P41212
Unit cell:
a: 74.85Å b: 74.85Å c: 139.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.19 0.23
Expression systems:
  • Escherichia coli
  • Not provided