PDBe 4pvn


Neutron structure of human transthyretin (TTR) at room temperature to 2.3A resolution (monochromatic)


Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 130 amino acids
Theoretical weight: 14.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Experimental Method: Neutron Diffraction, X-ray diffraction
Spacegroup: P21212
Unit cell:
a: 43.68Å b: 86.26Å c: 65.72Å α: 90° β: 90° γ: 90°
R R work R free 0.212 0.209 0.262
Expression system: Escherichia coli