PDBe 4puz

X-ray diffraction
2.08Å resolution

Crystal structure of spleen tyrosine kinase (Syk) in complex with GS-9973


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase SYK Chains: A, B
Molecule details ›
Chains: A, B
Length: 291 amino acids
Theoretical weight: 33.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P43405 (Residues: 353-635; Coverage: 45%)
Gene name: SYK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P1
Unit cell:
a: 39.882Å b: 41.877Å c: 87.405Å
α: 98.67° β: 90.43° γ: 101.38°
R R work R free
0.213 0.21 0.261
Expression system: Spodoptera frugiperda