PDBe 4pmf

X-ray diffraction
1.35Å resolution

Human transthyretin (TTR) complexed with curcumin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 117 amino acids
Theoretical weight: 12.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 29-145; Coverage: 92%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 43.255Å b: 85.487Å c: 64.168Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.209