PDBe 4pme

X-ray diffraction
1.26Å resolution

Human transthyretin (TTR) complexed with ferulic acid and curcumin.

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 12.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 29-146; Coverage: 93%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 42.99Å b: 84.67Å c: 64.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.207