PDBe 4p4k

X-ray diffraction
2.8Å resolution

Structural Basis of Chronic Beryllium Disease: Bridging the Gap Between allergic hypersensitivity and auto immunity

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class II histocompatibility antigen, DP alpha 1 chain Chains: A, E
Molecule details ›
Chains: A, E
Length: 183 amino acids
Theoretical weight: 21.17 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P20036 (Residues: 32-214; Coverage: 79%)
Gene names: HLA-DP1A, HLA-DPA1, HLASB
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DP beta 1 chain Chains: B, F
Molecule details ›
Chains: B, F
Length: 212 amino acids
Theoretical weight: 24.39 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P04440 (Residues: 16-17, 32-218; Coverage: 76%)
Gene names: HLA-DP1B, HLA-DPB1
Sequence domains:
Structure domains:
T cell receptor alpha constant Chains: C, G
Molecule details ›
Chains: C, G
Length: 209 amino acids
Theoretical weight: 23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01848 (Residues: 1-93; Coverage: 66%)
Gene names: TCRA, TRAC
Sequence domains: Domain of unknown function (DUF1968)
Structure domains: Immunoglobulins
T cell receptor beta constant 2 Chains: D, H
Molecule details ›
Chains: D, H
Length: 242 amino acids
Theoretical weight: 27.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A5B9 (Residues: 1-129; Coverage: 73%)
Gene names: TCRBC2, TRBC2
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X26C
Spacegroup: P212121
Unit cell:
a: 79.4Å b: 137.24Å c: 213.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.252
Expression systems:
  • unidentified baculovirus
  • Escherichia coli