PDBe 4ong

X-ray diffraction
2.2Å resolution

Fab fragment of 3D6 in complex with amyloid beta 1-40

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Amyloid-beta protein 40 Chain: P
Molecule details ›
Chain: P
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
3D6 FAB ANTIBODY HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.83 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
3D6 FAB ANTIBODY LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.26 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P2221
Unit cell:
a: 40.04Å b: 84.94Å c: 175.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.227
Expression systems:
  • Not provided
  • Cricetulus griseus