PDBe 4onf

X-ray diffraction
2Å resolution

Fab fragment of 3D6 in complex with amyloid beta 1-7

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Amyloid-beta protein 40 Chain: P
Molecule details ›
Chain: P
Length: 7 amino acids
Theoretical weight: 891 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-678; Coverage: 1%)
Gene names: A4, AD1, APP
3D6 FAB ANTIBODY HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.83 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
3D6 FAB ANTIBODY LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.26 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: C2
Unit cell:
a: 126.81Å b: 69.44Å c: 61.73Å
α: 90° β: 115.43° γ: 90°
R-values:
R R work R free
0.16 0.158 0.204
Expression systems:
  • Not provided
  • Cricetulus griseus