PDBe 4ojf

X-ray diffraction
2Å resolution

Humanised 3D6 Fab complexed to amyloid beta 1-8

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Humanised 3D6 Fab Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.26 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Humanised 3D6 Fab Light Chain Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.03 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Amyloid-beta protein 40 Chain: A
Molecule details ›
Chain: A
Length: 8 amino acids
Theoretical weight: 978 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: NEW P05067 (Residues: 672-679; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Unit cell:
a: 60.162Å b: 83.43Å c: 88.248Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.215
Expression systems:
  • Homo sapiens
  • Not provided