PDBe 4ohh

X-ray diffraction
2.7Å resolution

LEOPARD Syndrome-Associated SHP2/Q506P mutant

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein phosphatase non-receptor type 11 Chain: A
Molecule details ›
Chain: A
Length: 536 amino acids
Theoretical weight: 61.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q06124 (Residues: 1-532; Coverage: 88%)
  • Best match: Q06124-3 (Residues: 1-459)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 54.517Å b: 222.185Å c: 40.858Å
α: 90° β: 90° γ: 90°
R R work R free
0.206 0.202 0.266
Expression system: Escherichia coli BL21(DE3)