PDBe 4o02

X-ray diffraction
3.6Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Integrin alpha-V Chain: A
Molecule details ›
Chain: A
Length: 962 amino acids
Theoretical weight: 106.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P06756 (Residues: 31-992; Coverage: 95%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Structure domains:
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 692 amino acids
Theoretical weight: 76.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P05106 (Residues: 27-718; Coverage: 91%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:
17E6 light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.71 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
17E6 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.3 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 110.464Å b: 266.988Å c: 102.163Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.246 0.312
Expression system: Spodoptera frugiperda