PDBe 4nwf

X-ray diffraction
2.1Å resolution

Crystal structure of the tyrosine phosphatase SHP-2 with N308D mutation

Source organism: Homo sapiens
Entry authors: Qiu W, Lin A, Hutchinson A, Romanov V, Ruzanov M, Thompson C, Lam K, Kisselman G, Battalie K, Chirgadze NY

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein phosphatase non-receptor type 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 539 amino acids
Theoretical weight: 62.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q06124 (Residues: 1-543; Coverage: 90%)
  • Best match: Q06124-2 (Residues: 1-539)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 211.28Å b: 55.88Å c: 91.629Å
α: 90° β: 90° γ: 90°
R R work R free
0.267 0.266 0.309
Expression system: Escherichia coli