PDBe 4nw6

X-ray diffraction
1.74Å resolution

Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-3 Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 37.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P51812 (Residues: 39-359; Coverage: 43%)
Gene names: ISPK1, MAPKAPK1B, RPS6KA3, RSK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 51.87Å b: 60.53Å c: 112.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.165 0.201
Expression system: Spodoptera frugiperda