PDBe 4no7

X-ray diffraction
1.7Å resolution

Human Glucokinase in complex with a nanomolar activator.

Source organism: Homo sapiens
Primary publication:
The active conformation of human glucokinase is not altered by allosteric activators.
Acta Crystallogr. D Biol. Crystallogr. 67 929-35 (2011)
PMID: 22101819

Function and Biology Details

Reaction catalysed:
ATP + D-glucose = ADP + D-glucose 6-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Glucokinase Chain: A
Molecule details ›
Chain: A
Length: 470 amino acids
Theoretical weight: 53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: P35557 (Residues: 12-465; Coverage: 98%)
Gene name: GCK
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 66.3Å b: 81.3Å c: 85.5Å
α: 90° β: 90° γ: 90°
R R work R free
0.191 0.19 0.223
Expression system: Escherichia coli BL21