› 4nfn

X-ray diffraction
1.42Å resolution

Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol

Released:
DOI: 10.2210/pdb4nfn/pdb
PDB entry 4nfn coloured by chain, front view.
PDB entry 4nfn coloured by chain, side view.
PDB entry 4nfn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.
Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S
Acta Crystallogr F Struct Biol Commun 70 173-81 (2014)
PMID: 24637750

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178328 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tau-tubulin kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5TCY1 (Residues: 14-320; Coverage: 23%)
Gene names: BDTK, KIAA1855, TTBK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 2KC 1 x 2KC
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 169.49Å b: 39.91Å c: 50.53Å
α: 90° β: 105.34° γ: 90°
R-values:
R R work R free
0.186 0.185 0.209
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Tau-tubulin kinase.
Ikezu et al. (2014)
3 more

2 mentions without citation

The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.
Kiefer et al. (2014)
1 more