PDBe 4nen

X-ray diffraction
2.9Å resolution

An internal ligand-bound, metastable state of a leukocyte integrin, aXb2

Released:
Source organism: Homo sapiens
Primary publication:
An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2.
OpenAccess logo J. Cell Biol. 203 629-42 (2013)
PMID: 24385486

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin alpha-X Chain: A
Molecule details ›
Chain: A
Length: 1094 amino acids
Theoretical weight: 120.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20702 (Residues: 20-1101; Coverage: 95%)
Gene names: CD11C, ITGAX
Sequence domains:
Structure domains:
Integrin beta-2 Chain: B
Molecule details ›
Chain: B
Length: 686 amino acids
Theoretical weight: 75.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 23-696; Coverage: 90%)
Gene names: CD18, ITGB2, MFI7
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 127.087Å b: 119.851Å c: 182.399Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.224 0.264
Expression system: Homo sapiens