PDBe 4n9j

X-ray diffraction
2.6Å resolution

Crystal structure of the cryptic polo box domain of human Plk4

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 228 amino acids
Theoretical weight: 26.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00444 (Residues: 581-808; Coverage: 24%)
Gene names: PLK4, SAK, STK18

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P6122
Unit cell:
a: 128.063Å b: 128.063Å c: 168.357Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.202 0.249
Expression system: Escherichia coli