PDBe 4n7v

X-ray diffraction
2.76Å resolution

Crystal structure of human Plk4 cryptic polo box (CPB) in complex with a Cep152 N-terminal fragment

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Centrosomal protein of 152 kDa Chain: C
Molecule details ›
Chain: C
Length: 60 amino acids
Theoretical weight: 6.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94986 (Residues: 1-60; Coverage: 4%)
Gene names: CEP152, KIAA0912
Serine/threonine-protein kinase PLK4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 229 amino acids
Theoretical weight: 26.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00444 (Residues: 580-808; Coverage: 24%)
Gene names: PLK4, SAK, STK18

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21212
Unit cell:
a: 126.551Å b: 63.942Å c: 79.499Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.261 0.258 0.288
Expression system: Escherichia coli