PDBe 4n4w

X-ray diffraction
2.8Å resolution

Structure of the human smoothened receptor in complex with SANT-1.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome b(562); Smoothened homolog Chain: A
Molecule details ›
Chain: A
Length: 475 amino acids
Theoretical weight: 53.12 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q99835 (Residues: 190-555; Coverage: 48%)
  • Canonical: Q0SXH8 (Residues: 23-128; Coverage: 100%)
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Gene names: SFV_4255, SMO, SMOH, cybC
Sequence domains:
Structure domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2221
Unit cell:
a: 84.64Å b: 110.88Å c: 145.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.204 0.253
Expression system: Spodoptera frugiperda