PDBe 4n4h

X-ray diffraction
2.3Å resolution

Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.1K36me3

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Zinc finger MYND domain-containing protein 11 Chain: A
Molecule details ›
Chain: A
Length: 252 amino acids
Theoretical weight: 29.5 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8R5C8 (Residues: 154-371; Coverage: 36%)
Gene name: Zmynd11
Sequence domains:
Structure domains:
Histone H3.1 Chain: B
Molecule details ›
Chain: B
Length: 22 amino acids
Theoretical weight: 2.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 22-43; Coverage: 16%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P43212
Unit cell:
a: 64.358Å b: 64.358Å c: 122.059Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.206 0.263
Expression systems:
  • Escherichia coli
  • Not provided