PDBe 4n0f

X-ray diffraction
3.02Å resolution

Human FcRn complexed with human serum albumin

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
IgG receptor FcRn large subunit p51 Chains: A, E, H, K
Molecule details ›
Chains: A, E, H, K
Length: 271 amino acids
Theoretical weight: 30.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P55899 (Residues: 27-297; Coverage: 79%)
Gene names: FCGRT, FCRN
Sequence domains: Immunoglobulin C1-set domain
Structure domains:
Beta-2-microglobulin Chains: B, F, I, L
Molecule details ›
Chains: B, F, I, L
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Serum albumin Chains: D, G, J, M
Molecule details ›
Chains: D, G, J, M
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 136.469Å b: 115.925Å c: 186.237Å
α: 90° β: 104.47° γ: 90°
R-values:
R R work R free
0.225 0.223 0.26