PDBe 4mzg

X-ray diffraction
1.7Å resolution

Crystal structure of human Spindlin1 bound to histone H3K4me3 peptide

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone H3.2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q71DI3 (Residues: 2-21; Coverage: 15%)
Gene names: H3F2, H3FM, HIST2H3A, HIST2H3C, HIST2H3D
Spindlin-1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 222 amino acids
Theoretical weight: 25.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y657 (Residues: 50-262; Coverage: 81%)
Gene names: OCR, SPIN, SPIN1
Sequence domains: Spin/Ssty Family
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 43.168Å b: 122.037Å c: 49.837Å
α: 90° β: 91.71° γ: 90°
R-values:
R R work R free
0.184 0.183 0.207
Expression systems:
  • Not provided
  • Escherichia coli