PDBe 4mqj

X-ray diffraction
1.8Å resolution

Structure of Wild-type Fetal Human Hemoglobin HbF

Released:
Source organism: Homo sapiens
Entry authors: Soman J, Olson JS

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit gamma-2 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 146 amino acids
Theoretical weight: 16.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P69892 (Residues: 3-147; Coverage: 99%)
Gene name: HBG2
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21
Unit cell:
a: 105.651Å b: 52.427Å c: 106.153Å
α: 90° β: 113.84° γ: 90°
R-values:
R R work R free
0.18 0.18 0.215
Expression system: Escherichia coli