PDBe 4mj2

X-ray diffraction
2.1Å resolution

Crystal structure of apo-iduronidase in the R3 form

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-L-iduronidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 653 amino acids
Theoretical weight: 72.69 KDa
Source organism: Homo sapiens
Expression system: Arabidopsis thaliana
UniProt:
  • Canonical: NEW P35475 (Residues: 1-653; Coverage: 100%)
Gene name: IDUA
Sequence domains: Glycosyl hydrolases family 39
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: R3
Unit cell:
a: 259.36Å b: 259.36Å c: 71.81Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.191 0.206
Expression system: Arabidopsis thaliana