PDBe 4mdr

X-ray diffraction
1.85Å resolution

Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C31 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.3 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 758-767; Coverage: 1%)
Gene names: A4, AD1, APP
AP-4 complex subunit mu-1 Chain: A
Molecule details ›
Chain: A
Length: 301 amino acids
Theoretical weight: 33.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00189 (Residues: 160-453; Coverage: 65%)
Gene names: AP4M1, MUARP2
Sequence domains: Adaptor complexes medium subunit family
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 46.507Å b: 56.729Å c: 60.18Å
α: 90° β: 106.67° γ: 90°
R-values:
R R work R free
0.216 0.214 0.26
Expression systems:
  • Not provided
  • Escherichia coli