PDBe 4ll4

X-ray diffraction
2.7Å resolution

The structure of the TRX and TXNIP complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thioredoxin-interacting protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 315 amino acids
Theoretical weight: 35.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H3M7 (Residues: 3-317; Coverage: 81%)
Gene names: TXNIP, VDUP1
Sequence domains:
Structure domains: Immunoglobulin-like
Thioredoxin Chains: B, D
Molecule details ›
Chains: B, D
Length: 105 amino acids
Theoretical weight: 11.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10599 (Residues: 1-105; Coverage: 100%)
Gene names: TRDX, TRX, TRX1, TXN
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P21
Unit cell:
a: 79.826Å b: 64.99Å c: 88.416Å
α: 90° β: 90.88° γ: 90°
R-values:
R R work R free
0.201 0.196 0.264
Expression system: Escherichia coli