PDBe 4lhu

X-ray diffraction
2.87Å resolution

Crystal Structure of 9C2 TCR bound to CD1d

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Antigen-presenting glycoprotein CD1d Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 31.76 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P15813 (Residues: 24-295; Coverage: 86%)
Gene name: CD1D
Sequence domains: Immunoglobulin C1-set domain
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
TRA@ protein Chain: D
Molecule details ›
Chain: D
Length: 236 amino acids
Theoretical weight: 26.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PJ56 (Residues: 21-252; Coverage: 82%)
Gene name: TRA@
Sequence domains:
Structure domains: Immunoglobulins
T cell receptor gamma constant 1 Chain: G
Molecule details ›
Chain: G
Length: 251 amino acids
Theoretical weight: 28.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0CF51 (Residues: 1-122; Coverage: 71%)
Gene names: TCRGC1, TRGC1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2221
Unit cell:
a: 131.62Å b: 152.69Å c: 135.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.243
Expression systems:
  • Trichoplusia ni
  • Homo sapiens